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It’s no secret that I’m not very fond of butlers and waiters, but I was pleasantly surprised by this recent picture from the set of The Poolboy. It looks like the little guy is wielding a rifle, but the text on the bottom of the picture reads, “Cameo role, Nickelodeon,” which is why I’m assuming it’s a fake, even though it’s wearing a really stupid outfit.
The Poolboy is about a 17-year-old pool boy who finds love with the two most beautiful people in his life. Paul Scheer, who was also in The League, plays the pool boy, and it appears as though he’s not doing much. Maybe he’s been sitting on his ass for the last 14 years?
Anyway, watch for a little teaser clip of the movie when it airs on Nick at Nite. This looks really funny!Pharmacology and therapeutic potential of the histone deacetylase inhibitor suberoylanilide hydroxamic acid.
Histone deacetylases (HDACs) regulate transcription by modifying chromatin architecture, which may be altered by cancer therapy. Suberoylanilide hydroxamic acid (SAHA) is a novel HDAC inhibitor developed by Abbott Laboratories. The primary mechanism of action involves its interaction with class I HDACs, which catalyze the removal of acetyl groups from specific lysine residues of core histones, thereby changing chromatin structure. As a result of chromatin remodeling, transcription is activated or suppressed. A wealth of data exists that demonstrates that SAHA induces differentiation, apoptosis, and growth inhibition in a variety of cancer cell lines. It is currently being evaluated in clinical trials as a single agent and in combination with radiation, chemotherapy,
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