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MAPK p38alpha expression in tumours of patients with endometrial cancer.
Increased expression of stress response genes including p38 kinase is observed in human cancer cells. The present study was performed to evaluate the expression of p38alpha protein in clinical samples of endometrial cancer by immunohistochemical analysis. Paraffin-embedded tumour sections from 95 patients with endometrial cancer were studied. Immunohistochemical staining of p38alpha was performed and the staining was graded by an expert pathologist as low (+), moderate (++), or high (+++) to determine the immunoreactivity of the sample. We could find a significant difference in p38alpha expression among different clinical stages of endometrial cancer patients (P=0.0014). The p38alpha expression was significantly increased in endometrioid adenocarcinoma as compared to other types of endometrial cancer (P=0.0288). In other types of endometrial cancer, there were no statistical difference in p38alpha expression between endometrioid and serous carcinoma (P=0.1443), or between serous and clear cell carcinoma (P=0.2858). The expression of p38alpha did not correlate with lymph node metastasis (P=0.5489). There was no correlation between p38alpha expression and tumour recurrence (P=0.6573). The present study suggests that p38alpha expression may be correlated with endometrial cancer progression.Q:
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