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Activation of retinoic acid receptor RXR alpha promotes apoptosis in human hepatoma cells.
Our previous study has demonstrated that a retinoid X receptor (RXR) is expressed in human hepatoma cell line L-02. In the present study, we investigated the role of RXR alpha in human hepatoma cells. We found that the treatment of L-02 cells with RXR alpha agonists, 9-cis retinoic acid (9-cis RA) and borrelidin, causes L-02 cells to undergo apoptosis. Conversely, retinoic acid receptor antagonist, hydroxyflutamide, attenuated this apoptosis. The introduction of RXR alpha into L-02 cells which poorly express RXR alpha caused an increase in cell survival, while the introduction of RXR alpha into HeLa cells, which express high level RXR alpha, caused an increase in cell death. Further analysis revealed that the introduction of RXR alpha promotes Bax and inhibits c-FLIP expression in L-02 cells. When RXR alpha and anti-apoptotic Bcl-2 were introduced into L-02 cells, an increase in cell death was observed. Thus, we conclude that RXR alpha, but not all RXR subtypes, has a pro-apoptotic function in human hepatoma cells.Realm of the Giants (Pantheon)
The Realm of the Giants (or Pantheon) is an ancient Roman temple complex in the Roman Forum excavated in the 16th century. It is a rotunda, originally dedicated to Jupiter, god of the sky. It was converted into a locus deity on the orders of Augustus, god of the sun, who decided to intercede with Jupiter to build a temple in the forum, as it was too hot to stand in on the Palatine. The Temple of Saturn may have been on this site.
The temple itself was destroyed during the construction of the temple of Antoninus and Faustina in the middle of the 3rd century AD, which may also account for the lack of inscriptions. The site now lies below Piazza del
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