F1 Rft 2012 Setups
RFT 2012 Montreal – 1.14.287 HD + Setup. 319 views319 views. August 21, 2013 3. Don’t like it. Share. Save. Daniel Rigoni. Daniel Rigoni. 11 followers. Subscribe. Share. Save. Daniel Rigoni. Daniel Rigoni. 11 followers. Subscribe. Share. Save. Daniel Rigoni. Daniel Rigoni. 11 followers. Subscribe. Share. Save. Daniel Rigoni. Daniel Rigoni. 11 followers. Subscribe. Share. Save. Daniel Rigoni. Daniel Rigoni. 11 followers. Subscribe. Share. Save. Daniel Rigoni. Daniel Rigoni. 11 followers. Subscribe. Share. Save. Daniel Rigoni. Daniel Rigoni. 11 subscribers.
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Biodegradable liposomes encapsulating chitosan nanoparticles were designed and evaluated to improve the encapsulation efficiency of the model drug doxorubicin hydrochloride (DOX). The liposomes were prepared by the thin-film drying method using distearoylphosphatidylcholine (DSPC), cholesterol (Chol), and phospholipid-coated chitosan nanoparticles (Chitosan-NPs). The effects of chitosan-NP concentrations (0.0-1.0 wt%), chitosan molecular weight (0.5-5 kDa), and chitosan-NP concentrations (0.5-2.0 mg/ml) on DOX encapsulation efficiency were investigated. Encapsulation efficiency increased by increasing the DOX concentration and decreasing DOX-NP concentration in the liposomes, due to increased DOX deposition. Biocompatibility was assessed for the formulations in mice. A significant toxic effect on the liver and a mild toxic effect on the spleen were observed at high chitosan-NP concentrations of 2.0 mg/ml. Moreover, the in vivo oral bioavailability of the DOX liposomes with and without the Chitosan-NP was compared in mice. This study showed that DOX liposomes with Chitosan-NP are a promising vehicle for oral delivery of DOX.atements || []).push(at);
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