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GBR7 (growth factor receptor-bound protein 7) is a member of the GRB (growth factor receptor-bound protein) family of adaptor proteins. GBR7 is ubiquitously expressed and is highly induced in response to growth factors and oncogenes. It may act as a link between receptor tyrosine kinases (RTKs) and downstream signalling cascades, such as mitogen-activated protein kinase (MAPK) cascades. Moreover, GBR7 participates in other important signalling cascades, such as the Wnt and nuclear factor-kappaB (NF-kappaB) pathways. GBR7 is localized at the cell membrane and may function there as a membrane-bound adaptor protein between growth factor receptors and downstream signalling molecules. Although the exact mechanisms are unknown, the available data suggest a role for GBR7 in negative and positive regulation of signal transduction. GBR7 may also be important for cell migration and invasion. GBR7 is also involved in other aspects of cell biology, such as the cell cycle and apoptosis. In addition, GBR7 may be involved in disease, especially cancer. In this review we describe the putative functions and signalling pathways in which GBR7 is involved and discuss the biological roles of GBR7 in different cell types.Q:
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