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Ulike Class 9 Maths Download Pdf
Sample CBSE 9th grade math solved problems, as well as several sets of unsolved problems, are available in pdf format for students to practice. Download them to earn points. The following branches of mathematics are represented at CBSE:
The problem book is part of the number theory textbook for CBSE students. The collection is compiled in the form of number theory exercises, which are divided into 12 categories. Each category contains tasks of different difficulty levels. Some problems are presented as pictures and others as math expressions.
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T2DM is an obesity-induced inflammation syndrome characterized by chronic activation of the innate immune system in conjunction with the progression of insulin resistance and pancreatic β-cell dysfunction. Macrophages and adipose tissue contribute to the development of obesity-induced T2DM by secreting pro-inflammatory cytokines.^[@bib21]^ IL-6 is an important mediator of the progression of obesity-induced T2DM, and IL-6 levels in the plasma increase with the progression of T2DM.^[@bib22]^ The results of our study demonstrate that ART administration attenuates the development of obesity-induced inflammation by inhibiting macrophage activation and cytokine secretion, thus delaying the progression of diabetes. We also observed significant decreases in IL-6 levels in both ART- and pioglitazone-treated mice. These results are consistent with the results of clinical studies that have shown that the plasma levels of IL-6 are reduced by pioglitazone.^[@bib23]^ Our results suggest that the anti-inflammatory effects of ART are similar to those of pioglitazone and that ART may be a good therapeutic agent for the treatment of T2DM.
In conclusion, we demonstrated that ART can effectively improve hyperglycemia and dyslipidemia in *db/db* mice. We also found that ART ameliorates the hyperglycemia in *db/db* mice by suppressing inflammatory signals via inhibition of macrophage activation and cytokine secretion and subsequent enhancement of insulin sensitivity.
This work was supported by grants from the Korea Health technology R&D Project, Ministry for Health and Welfare, Republic of Korea (A102255 to S.L and H.S.). We thank Drs Jae-Goo Park and Mi-Hee Kang for conducting the animal experiments and Hye Jin Kim for assistance with the experimental work.
The authors declare no conflict of interest.
{#fig1}
![ART treatment attenuates the development of hyperglycemia in *db/db* mice. Body weight was monitored for 7 weeks (**a**), and blood glucose was measured at 3, 5, 7, 10, 13 and 15 weeks of age (**b**
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