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Serum concentrations of digoxin were monitored during therapy with digoxin in 60 subjects with heart failure. No dose-response relationship was observed. A continuous decline of serum digoxin concentrations after initiation of therapy occurred in 40% of patients. After adjustment for mean dose, the mean rate of decline of serum concentrations was 0.035 ng/ml per day, with a peak-trough variation of -0.25-0.50 ng/ml. Digoxin therapy was discontinued in two patients with chronic atrial fibrillation because of a mean steady-state concentration of 0.13 ng/ml or greater. Digoxin was successfully reinstituted in one patient after a period of interruption. The results indicate that mean serum concentration monitoring is not necessary during clinical management of patients with heart failure. Laboratory monitoring may be useful in patients with atrial fibrillation or when digoxin is discontinued.Increased serotonin-dopamine turnover in the prefrontal cortex of mice deficient in serotonin transporter expression.
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