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Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene. UBE2C belongs to the ubiquitin-conjugating enzyme family.
Function
Ubiquitin conjugating enzymes are a family of heterodimeric enzymes with a cysteine-dependent thioesterase and a ubiquitin-conjugating activity. They catalyze the formation of an isopeptide bond between the C terminus of ubiquitin and a specific lysine residue on a target protein. The ubiquitin-conjugating enzymes are required for the ubiquitination and subsequent degradation of a variety of cellular proteins. This gene encodes a member of the ubiquitin-conjugating enzyme family. Transcript variants encoding different isoforms have been identified.
Interactions
UBE2C has been shown to interact with:
CDC20,
Myc,
Numb,
PTTG1
SIAH1, and
Siah1 (proteosome regulator)
References
Further reading
External links
PDBe-KB provides an overview of all the structure information available in the PDB for Human UBE2CQ:
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Size:
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