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It has been shown that genistein influences a different set of genes in the malignant breast cancer cell lines compared to those in the normal cells. Particularly, the function of p53 as a driver of apoptosis in the presence of genistein and estrogens, as well as the role of cell cycle checkpoint regulation, epigenetic alteration, metastasis, cell invasion, and angiogenesis. The above-mentioned roles in inducing apoptosis suggest a possible link between the effect of genistein and the p53 status \[[@B55-ijms-20-02913],[@B59-ijms-20-02913]\]. The influence of p53 on apoptotic and angiogenic pathways is described in a subsequent section.
As described in the present study, the use of the structural hypothesis and functional studies that consider the effect of genistein on the expression and regulation of p53, allows for the identification of targets and the better understanding of the breast cancer molecular mechanisms; and to assess the pathophysiological mechanism that might be involved in patients with this disease, as well as the identification of the role of p53 in the presence of genistein. In addition, the previous analysis of the functional role of p53 in cancerous cells (using genistein and doxorubicin) highlighted that the modification of p53-induced apoptosis is
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Two types of feed horns are used for the transmit-receive antennas: a circular-sector type and a rectangular type. Although both types of horns are practically used to transmit and receive radio waves, the circular-sector type is advantageous in comparison with the rectangular type for a small antenna in that it is easier to feed an antenna. The transmitter and receiver are covered with a radome. At the time of the transmission, the radome is accommodated to the antenna element to protect the transmitter and the receiver. When the received waves are not much, the radome is opened to receive the radio waves.
Japanese Unexamined Patent Application Publication No. 2003-49395 (Patent Document 1) proposes an antenna device that has two phase coils wound around a radome and is provided with a single fixed dipole-type antenna element. Japanese Unexamined Patent Application Publication No. 6-80334 (Patent Document 2) proposes a transmission-receive antenna device comprising a horn antenna and a waveguide.Q:
What is the number on the ram chip (DDR1-2, 2x256M)?
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