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FullFileName: XMenLegendsIIRiseofApocalypsePCHighlyCompressed241MBrar
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Md5: 96609536398713b7ed6a468a47a437da9
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FileFullPath: /5557B3EB-FE64-43F8-9B42-2B87BD872278
IsVideo: True
FileExtension: m4a
Status: TrueIntroduction
============
Plasma cells are a type of white blood cell that reside in the bone marrow and produce antibodies. Among the more than 20 known antibodies, anti-neutrophil cytoplasmic antibodies (ANCAs) are associated with many chronic and debilitating autoimmune disorders. Despite the significance of ANCAs, little is known about the role of ANCAs in the pathogenesis of autoimmune inflammatory disorders, as well as the normal function of plasma cells in the adult.
Methods
=======
In this study, we used expression cloning to identify the ligands and receptors of both mature and immature B cells as well as the plasma cells that resided in the adult mice.
Results
=======
We found that members of the C1q and collectins family, including Macrosin, PLUNC and CL-K1/MFG-E8, were the cognate ligands for mature B cells. Macrosin/PLUNC chimeric proteins were recognized by mature naïve B cells with nearly 100% specificity. In contrast, PLUNC and CL-K1 did not bind to mature B cells, suggesting the existence of unidentified lectins. IgM^+^CD138^-^B220^+^plasma cells expressed a CL-K1 chimera that was reactive to immature B cells. Moreover, IgM^+^CD138^-^B220^+^plasma cells expressed a specific FcRγ-derived receptor, which was reactive to CL-K1. Finally, this receptor bound to the complex formed by the B cell receptor, the Ig, and Macrosin/PLUNC
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