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Our previous studies have shown that genistein, a soybean isoflavone, acts as a multikinase inhibitor in cancer cells. In this study, we have further investigated its antiproliferative activity in vitro on cultured human neuroblastoma cells. Neuroblastoma is the most common neoplasm of childhood and has a relatively poor prognosis in many cases. Our data indicate that genistein inhibited the growth of all tested neuroblastoma cells, irrespective of their degree of differentiation and tumorigenicity in nude mice. Furthermore, the effect of genistein was much more pronounced in the neuroblastoma cells that are more sensitive to the apoptotic process and that express high levels of topoisomerase IIalpha. It is thus very likely that genistein inhibits tumor growth by triggering a process that controls entry of cancer cells into mitosis. The fact that only part of the neuroblastoma cells were resistant to genistein suggested the possibility that some proteins may activate the efflux of the drug out of the cells. Our results thus add new elements to the mechanism of action of genistein, a soybean isoflavone.Japan’s Asahi TV distributes English-language TV for the first time
Japanese broadcasting giant Asahi TV plans to begin broadcasting television programs available in English in April on Dish Network in the U.S., Asahi’s new network partner, marking the first time in Japan that a local broadcasting company is providing U.S.-based cable and satellite subscribers with English-language television programming.
“Asahi TV will be
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