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HIF-1alpha transactivates CXCL12 in human breast cancer cells.
Hypoxia inducible factor-1alpha (HIF-1alpha) is frequently overexpressed in a variety of solid tumors, including breast cancer, and plays a role in tumor progression. CXCL12, a chemokine involved in homing and metastasis, is a target of HIF-1alpha. We have determined the effects of HIF-1alpha on CXCL12 production in human breast cancer cells. Estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB231 breast cancer cells were stably transfected with HIF-1alpha expression plasmid. Enzyme-linked immunosorbent assay (ELISA) revealed a significant 2-5-fold increase of CXCL

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ThcCreditCardGeneratorSoftware69

ThcCreditCardGeneratorSoftware69

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